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In methotrexate-induced ovarian damage, pretreatment with lycopene at 5 mg/kg body weight for 5 days prevented infertility and has shown to mediate increased GSH activity as well as decreased MDA and myeloperoxidase concentrations [211]

Baxter et al

Philbert MA, Beiswanger CM, Waters DK, Reuhl KR, Lowndes HE

Gradual reduction of dark spots and hyperpigmentation
