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CREB regulates gene expression of dynorphin, a protein that slows dopamine release, dampening the reward system

10.1016/j.biopsych.2012.01.014 [DOI] [PMC free article] [PubMed] [Google Scholar] 24.Wink LK, Adams R, Wang Z, Klaunig JE, Plawecki MH, Posey DJ, et al

A healthy liver influences energy, digestion, and fat metabolism

It is worth being precise about what a Phase 2 trial can and cannot establish
