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20 The toxins share multiple conserved domains including a catalytic glucosyltransferase domain located at the N-terminus and a cysteine protease domain which is required for auto-processing and delivery of the catalytic domain to the cytosol of the intoxicated cell

Statistical analysis Statistical analyses were performed using GraphPad Prism (Graphpad Software, version 8.4.3) or R (version 4.5.1)

A double stranded small-interfering RNA (siRNA) to the ANGPTL3 mRNA, that is conjugated to GalNAc (identified as ARO-ANG3), has shown promise at hepatocyte-specific reduction in ANGPTL3 mRNA levels