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Many MCAS patients have impaired pathways for converting glutamate into calming GABA, leading to "glutamate excitotoxicity"which can manifest as severe anxiety, insomnia, heart palpitations, and brain fog

[Crossref] Lehre KP, Levy LM, Ottersen OP, Storm-Mathisen J, Danbolt NC (1995) Differential Expression of Two Glial Glutamate Transporters in the Rat Brain: Quantitative and Immunocytochemical Observations

SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis

To critically appraise mechanisms and levels of evidence ( in vitro, in vivo , clinical) for vitamin E and C, glutathione and its precursors, polyphenols (quercetin, resveratrol, curcumin), Crocus sativus carotenoids (crocin/safranal), and indirect modulators (e.g., omega-3, folinic acid), emphasizing study quality, translational relevance, and limitations