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High dose intravenous (IV) thiamine supplementation (500 mg thiamin dissolved in 100 mL normal saline) led to a reduction in the frequency of migraine attacks ( Mitochondrial dysfunction theory is one of the hypotheses related to thiamine-migraine association ( Riboflavin Riboflavin is one of the most essential vitamins B due to its properties, such as anti-inflammatory, antioxidant, anti-nociceptive, and anti-aging ( Disruption in brain energy metabolism is considered a proposed cause of migraine attacks ( A randomized clinical trial (RCT) demonstrated that high-dose riboflavin supplementation (400 mg/d) could decrease the attack frequency, duration, severity, and number of headache days in adults with migraine, after 3 months

Histological studies demonstrate disorganised collagen fibres and increased matrix metalloproteinase activity within tendons, changes associated with oxidative stress and disrupted extracellular-matrix turnover (83)

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Familial Parkinsons disease-associated L166P mutation disrupts DJ-1 protein folding and function