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Exogenous supplementation of CoQ 10 is safe and does not affect its endogenous biosynthesis [181]
In organ transplantation, trained immunity has been shown to modulate the fate of grafts, as demonstrated in animal models
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Severely affected patients present in the first few days of life with non-ketotic hypoglycemia, hyperammonemia, and metabolic acidosis accompanied by hypotonia, encephalopathy, hepatomegaly, cardiomyopathy, and poor prognosis
