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NRF2 can activate downstream suppressor genes through transcription, the trans-sulfur pathway can convert methionine into cysteine, and the mTOR pathway can increase GPX4 protein synthesis, all of which can improve ferroptosis resistance [133]

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149 UPA inhibits the proliferation of cultured leiomyoma cells by downregulating PCNA and Bcl-2 expression and by upregulating cleaved caspase-3 and poly (ADP-ribose) polymerase expression