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Rommel P

Activation of mTOR in senescent cells contributes to cellular dysfunction and the pro-inflammatory SASP.134 Inhibition of mTOR has been shown to reduce the expression of SASP factors and improve tissue function in animal models of aging.135 Modulation of the SASP: Senescent cells secrete a variety of pro-inflammatory cytokines, chemokines, growth factors, and proteases collectively known as the SASP

These residues can undergo oxidation to form disulphide bonds and thus reduce PDI or an equivalent ER oxidoreductase

doi: 10.3390/foods13193135 214 Naissinger da SilvaMTagliapietraBLFloresVDA
