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Appropriate patient selection is essential, as current evidence suggests that only tumours with functional retinoblastoma (Rb) protein, low cyclin E expression, and intact immune signalling pathways are likely to respond favourably

[2] [53] [54] Laboratory investigations [edit] Urinalysis is typically performed when LUTS are present and BPH is suspected to evaluate for signs of a urinary tract infection, glucose in the urine (suggestive of diabetes), or protein in the urine (suggestive of kidney disease)

Menstrual cycles that are shorter than 21 days or longer than 35 days may indicate hormone imbalance and anovulation

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