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These TF act as epigenetic regulators of chromatin structure through interactions with histone modifiers, chromatin remodeling complexes, transcriptional regulators, and/or DNA methylation machinery that modulate gene expression

When our immune system is being utilized to fight infections or inflammation, it naturally consumes large amounts of ATP and other valuable resources as our body works to protect us and maintain proper balance and function

Because of the lack of stable 3D-structures, IDPs can sustain exposure to extremely harsh environmental conditions that would typically denature or unfold ordered proteins and render them dysfunctional (Uversky, 2017b)

Vitamin B12 is one of many B vitamins