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Additionally, ADP-ribosylation factor 6 (ARF6), a downstream effector of the KRAS/ERK signaling pathway, promotes the proliferation of PDAC cells
Combining KRASG12C inhibitors, such as sotorasib, as KRAS mutant tumors are highly dependent on GPx4 for survival
This negative study has however been criticized as being largely underpowered to detect any significant effects of inhaled NO
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