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Excessive Fe 2+ can react with lipid radicals and H 2 O 2 to produce a large amount of reactive oxygen species (ROS), which can damage membrane lipids, proteins, DNA, and other biological macromolecules, causing ferroptosis ( 3.2 Glutathione metabolism and ferroptosis GPX4 is an antioxidant enzyme found in mammalian cells

These enzymes include a limited number of dithiol Grx isoenzymes of humans, plants, and trypanosomes and virtually all monothiol Grx isoenzymes [161-163]