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In neurodegenerative disorders, pathological HDAC overactivity has been documented, leading to transcriptional silencing of neuroprotective genes (Saha and Pahan, 2006

These cells experience increased glucose and glutamine consumption due to aerobic glycolysis and increased cell proliferation (261, 262)

The burden of carbohydrates in health and disease

This reprogramming involves the downregulation of genes associated with proinflammatory responses and resistance to tissue invasion, along with the upregulation of genes that enhance cell proliferation, promote tolerance, and support tissue invasion ( As previously mentioned, one of the hallmarks of ferroptosis is iron accumulation