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Dana Parish: Nobody has told me that before about that tissue, and my internist has asked me about it many times over the years

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This patient's hyperacute 30-minute timeline to death and the lack of neutrophilic infiltrates on autopsy make bilateral bronchopneumonia unlikely

Metabolically constrained, potentially reversible dysfunction may be more amenable to strategies that restore mitochondrial fitness (e.g., redox modulation) and support lymphocyte recovery (e.g., IL-7/IL-15), whereas exhaustion-like states may require checkpoint modulation in combination with approaches that target upstream mitochondrial stress and the TOX/NR4Aepigenetic axis