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[15] [18] For borderline results, additional tests such as methylmalonic acid, homocysteine, or holotranscobalamin may be considered
& Bjalme-Evans, M
doi: 10.1016/j.bcab.2020.101789
However, chemical modifications have improved the drug-like characteristics of RNA modalities (Khvorova and Watts, 2017), rendering them safer and more stable in vivo , with half-lives extending over 6 months for Antisense Oligonucleotides (Scoles et al., 2019)
