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Research approaches include clinical studies of dialysis patients, animal models of chronic kidney disease (5/6 nephrectomy, adenine-induced nephropathy), and studies of isolated renal tubular cells

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A known limitation is the lack of responsiveness and sensitivity of the EDSS to detect disability changes, especially in domains beyond motor dysfunction (Inojosa et al., 2020)

4.4 Neonatal hypoxicischemic encephalopathy The pathophysiology of HIE involves hypoxicischemic injury, characterized by perturbations in mitochondrial dynamics and the inhibition of critical energy-producing pathways, including oxidative phosphorylation and fatty acid -oxidation ( -oxidation and its prior neuroprotective effects in adult ischemia models, it represents a biologically plausible candidate for investigation in neonatal brain injury