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Therefore, activation of Piezo1 channels may reduce the transition of astrocytes from an anti-inflammatory state to a proinflammatory state, thereby suppressing inflammation

Because it degrades in blood in a pathway involving amino-peptidases, it may not be suitable for people who take medications that inhibit or are metabolized by peptidases (e.g., captopril, a treatment for hypertension).4 Also, based on what we know about other therapeutic peptides, we would say DSIP is contraindicated for women who are pregnant or breastfeeding as well as people with a personal history of cancer

After reconstitution, peptides will remain stable for up to 30 days

It was demonstrated that phosphorylation at the Ser637 site stimulates Ser616 phosphorylation and that only the inhibition of downstream Ser616 phosphorylation results in mitochondrial elongation (Gonzalez et al., 2021)
