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Pathologically, the accumulation of free Fe 2 + in cells promotes the production of hydroxyl radicals that cause oxidative damage to DNA, proteins, and membrane lipids through Fenton reactions or iron-catalyzed Haber-Weiss reactions

Role of the Kidney in Blood Glucose Control Although the liver is the major site of glucose homeostasis, the kidney plays a vital role in the overall process of regulating the level of blood glucose
Kurz, T., Eaton, J.W
It is the same logic as a loading phase followed by a maintenance phase in many research protocols: front-load to establish, then hold with less