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Typically, -synuclein localizes to the mitochondria-associated membrane, and its presence may disrupt mitochondrial function by promoting the formation of the mitochondrial permeability transition pore (mPTP), leading to mitochondrial membrane potential (MMP) loss, subsequent mitochondrial degradation, and ultimately cell death (192)

AgeDependent Decrease in Glutamine Synthetase Expression in the Hippocampal Astroglia of the Triple Transgenic Alzheimer's Disease Mouse Model: Mechanism for Deficient Glutamatergic Transmission? Molecular Neurodegeneration 6: 55

When we make energy, we also make free radicals
