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a marker of long term blood glucose levels) are elevated (Fiiciolu 1994

These fractures impair quality of life and are associated with increased mortality

As just one example, a recent study demonstrated that, although the neuropathic pain induced by chemotherapeutic agents such as paclitaxel is mediated at the very early stage of its development by activation of the innate immune system, its resolution is actually dependent on the involvement of the adaptive immune system and more specifically the trafficking of CD8+ T cells into the dorsal root ganglia (129)

This dampening of the HPA stress response occurs without suppressing normal cortisol rhythms, suggesting that DSIP acts as a modulator rather than an inhibitor of stress signalling