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Epigallocatechin gallate (EGCG) is a key active component of green tea (Camellia sinensis) leaves

Lentigines assume a particular importance when their presence is associated with a variety of inherited systemic conditions, including Peutz-Jeghers, LEOPARD (multiple lentigines), and Carney syndromes, centrofacial lentiginosis, and Laugier-Hunziker syndrome (idiopathic lenticular mucocutaneous pigmentation)

This latter finding has been bolstered by the discovery that thyrotropin-releasing hormone (TRH) gene expression, which has long been known to play a role in the leptin-satiety pathway, is also affected by MC-4R stimulation