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Curr Neuropharmacol 21(2):353379 Morris R, Amaral DG, Bliss T, Duff K, OKeefe J (eds) (2024) The hippocampus book

When Vitamin C neutralizes a free radical, it becomes "spent" or oxidized

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For example, hypervitaminosis A can be caused by taking one large dose of over 200 mg of vitamin A, or chronic use of more than 10 times the recommended daily intake ( Vitamin A toxicity may lead to serious complications, such as increased spinal fluid pressure, coma, and potentially fatal organ damage ( Additionally, taking megadoses of vitamin D more than 50,000 IU daily over long periods can lead to high blood levels of calcium (hypercalcemia), which can lead to death ( Overdosing on other vitamins can likewise cause potentially fatal side effects, such as liver damage