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In addition, autophagy appears to have a crucial role in dampening the immune response after irradiation as depletion of key autophagy regulators ATG5 or ATG7, thereby blocking mitophagy, increased cytosolic mtDNA after radiotherapy [110]

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The response rate data reveals another important distinction

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Hypercalcemia induces targeted autophagic degradation of aquaporin-2 at the onset of nephrogenic diabetes insipidus

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