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Furthermore, considering the specific transporter SMCT2, highly expressed on CD4 + T cells, this biological characteristic provides an essential influx route for lactate ingestion

Considering the central role of mitochondrial dysfunction in initiating oxidative stress and apoptosis, intracellular ROS generation were further evaluated

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Additionally, several rare pathogenic variants in SCN9A have been identified in patients carrying small fiber neuropathy [92], further underscoring the critical involvement of this gene in potentiating the mechanism of neuropathic pain