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Among these, Bifidobacterium strains improved immune cell function and promoted tumor infiltration, demonstrating their ability to augment therapeutic responses [98, 99]

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211,212 Moreover, after revealing the crystal structure of SIRT5, researchers found that SIRT5 is also a lysine desuccinylase and demalonylase

Preclinical studies have indicated the potential efficacy of this approach across a range of diseases, including ischemia-reperfusion injury, neurodegenerative disorders, kidney diseases, acute respiratory distress syndrome, and cancer [124, 138,139,140,141,142,143]
