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1618 Low IIS activity leads to the translocation of DAF-16 to the nucleus, where DAF-16 either activates or represses the genes involved in the cellular stress response (e.g., heat-shock proteins, superoxide dismutase and catalase), metabolism and autophagy
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78 Moreover, glucose-6-phosphate dehydrogenase (G6PD), a pivotal enzyme in the PPP, also serves as a significant substrate for lactylation
