glutathione reductase smith et al 1988 NOX-like ROS production by reductase: iScience Schematic representation of the role
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They found that piperazine erastin significantly decreased the size and number of tumor foci in the liver of DEN/CCl4-induced mice and the volume of Bel-7402 cell xenografts, accompanied by reduced levels of GPX4 expression
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doi: 10.3390/antiox12091653 34
Laboratory studies utilizing controlled research protocols show significant improvements in structural markers, collagen organization, and cellular regeneration processes
