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Proc Natl Acad Sci U S A (1984) 81:740711.10.1073/pnas.81.23.7407 143 Oesch-BartlomowiczBHuelsterAWissOAntoniou-LipfertPDietrichCArandMet alAryl hydrocarbon receptor activation by cAMP vs

The crystal structures of inhibitor-complexed forms also indicate that Gly-473 to Thr-475 forms an oxyanion hole, which interacts with the oxyanion of the tetrahedral intermediate in the transition state

Extracellular matrix interactions provide tumor cells with an escape mechanism for commitment to differentiation

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