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Biol Trace Element Res (2015) 167(2):22535

Large-scale, controlled studies are needed before any conclusions can be drawn

Abnormal acylcarnitine profiles in urine can also be used as biomarkers for a variety of kidney diseases [257, 258]

Topiramate has been shown to be an effective and well-tolerated prophylactic medication for the treatment of migraine ( Therefore, this review elucidates the etiology, inducements, pathogenesis and treatment modalities of migraine, the clinical evidence that migraine is associated with oxidative stress and neurogenic inflammation, as well as the experimental evidence of antioxidant and anti-inflammatory effects of topiramate, which is of great significance for further research and exploration of the possible mechanisms of topiramate in the treatment of migraine by modulating oxidative stress and neurogenic inflammatory pathways