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Quercetin as a novel activator of L-type Ca(2+) channels in rat tail artery smooth muscle cells

The dose-response curve was obtained after the co-administration of fixed doses of tesofensine and 5-HTP based on fractions (1/2, 1/4, and 1/8) relative to their respective ED 30 values

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[1] Symptoms of B12 deficiency develop gradually and may include: Persistent fatigue and weakness Neurological symptoms such as paraesthesia (pins and needles), particularly in hands and feet Cognitive changes including memory problems or confusion Glossitis (sore, red tongue) and mouth ulcers Mood disturbances including depression or irritability Balance problems and difficulty walking Neurological complications can become irreversible if left untreated , making prompt diagnosis and treatment essential