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Similarly, Salacia chinensis bark extract, administered intraperitoneally at 5 mg/kg daily for 2 weeks in SCC xenograft-bearing mice, inhibited tumor growth by 54% and decreased proliferation marker Ki-67 expression, while sparing normal tissue architecture ( Syngeneic and Orthotopic Models: Orthotopic implantation of mouse oral cancer cells into immunocompetent mice offers tumor microenvironment fidelity and immune system engagement (Tinajero-Diaz et al., 2021