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Yamamoto K, Soeda Y, Kamisako T, Hosaka H, Fukano M, Sato H et al

Despite the preponderance of ubiquitylation in bioregulation, to date few cellular E3 ligase inhibitory factors have been characterized

MPTP can cross the bloodbrain barrier and be taken up by glial cells, where it is converted to 1-methyl-4-phenylpyridinium (MPP + ) by MAO-B [99]

Treatment often involves dietary changes or vitamin B12 supplements.
