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Whereas C57BL/6 mice develop compensatory concentric hypertrophy with diastolic dysfunction and fibrosis, BALB/c mice show severe LV dilation and systolic dysfunction (Peng et al., 2011), which is uncommon in patients with HFpEF and more resembles dilated cardiomyopathy

designed the thienopyridine skeleton ( Figure 18 ) and optimized this type IKK inhibitor through the modification of R 1 and R 2 substituent groups [183]

Millns JL, Dicken CH

By targeting iron-dependent lipid peroxidation, ferroptosis induction bypasses key resistance pathways associated with chemotherapy, radiotherapy, and immunotherapy, while exploiting glioblastomas metabolic vulnerabilities
