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It affects the activity of factors such as HIF-1 and activator protein 1 (AP-1), thereby altering gene expression and stimulating cancer cell proliferation [212, 213]

Results NPs induced synergistically-enhanced ferroptosis of CAFs In our work, to evaluate the impact of CAFs on CRC patient survival, tumor samples from GSE17538 and GSE87211 were grouped by CAF scores using microenvironment cell populations-counter (MCPcounter), estimating the proportion of immune and cancer cells (EPIC), and estimation of stromal and immune cells in malignant tumor tissues using expression data (ESTIMATE) 30,31,32,33,34