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It is likely that some steps of the biotransformation of arsenic that involve the formation of glutathione-bound species can occur also involving individual cysteine thiol groups or pairs of vicinal thiol groups in proteins, such as the catalytically essential thiol groups of enzymes and the regulatory elements of effector proteins that can be modulated by reversible glutathionylation (see further)

Trx1s activity is inhibited by binding to TXNIP and subsequent blocking of the active site [216]

However, consumption of any type of vegetarian diet dramatically increases the prevalence of vitamin B 12 deficiency in individuals across all age groups (127, 128)

Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism