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Zhao X, Kuryatov A, Lindstrom JM, Yeh JZ, Narahashi T (2001) Nootropic drug modulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons

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It causes activation of the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system

Differential diagnosis includes a bacterial infection at the bite site or a hypersensitivity reaction to tick saliva at the bite site usually within 48 hours, less than 5 cm in diameter and resolving within 48 hours
