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In animal studies, antagonism of NMDA receptors in intermediate neurons of the forebrain and thalamus reduces GABAergic function

Tau seeding, also present in AD (123, 311, 372376), has been reported in the brains of MS patients (140) and this tau deposition may produce demyelination through injury to oligodendrocytes (128)
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Gallicchio L, Calhoun C, Helzlsouer KJ
