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Angermayer had pushed DSouza to moderate his initial anything-goes instincts

GPD2 deficiency has been shown to lead to a reduction of the nucleocytoplasmic [NAD + ]/[NADH] that decreased the expression of mitochondrial SIRT5 desuccinylase, which increased mitochondrial protein lysine succinylation and decreased the activity of the mitochondrial fatty acid beta-oxidation pathway (Qu et al., 2024)
2020 doi: 10.1007/s10803-020-04685-z
"Social senses: G-protein-coupled receptor signaling pathways in Dictyostelium discoideum"