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[PMC free article] [PubMed] [Google Scholar] 96.Bi Y.-M., Wu Y.-T., Chen L., Tan Z.-B., Fan H.-J., Xie L.-P., Zhang W.-T., Chen H.-M., Li J., Liu B., et al

Its binding depends on heterodimerization of IL-1R1 with interleukin-1 receptor accessory protein (IL1RAP)

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The synergistic insulin secretion produced by simultaneous GIP and GLP-1 receptor activation is mechanistically distinct from what amylin/GLP-1 combinations provide, and the SURPASS trial data in diabetic populations is among the strongest in the field