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By activating soluble guanylate cyclase (sGC), NO elevates cyclic guanosine monophosphate (cGMP) levels, which relaxes smooth muscle and facilitates vasodilation (Wu et al., 2021)

Neurosurgery 1995;37:1080-7

They stated that the lower enzyme activity in the HBV-infected carcinoma tissue resulted from a further disruption in the antioxidant defense system (double insults of hepatocellular carcinoma and HBV infection)