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The mechanisms behind B12 deficiency in metformin users are multifactorial but are probably related to intestinal absorption, so it seems sensible to assume that oral B12 replacement may be less effective, although there is little evidence in this area

Lees studies are smaller than most rigorous clinical trials, ranging in size from two to 16 study participants, and dont include comparison groups

AOD-9604s GRAS determination was based on the extensive human safety data from its clinical trial program

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