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For instance, miR-22-3p and miR-149-5p bind the 3'UTR of MTHFR mRNA, and under folate deficiency, their upregulation suppresses MTHFR protein, further restricting one-carbon flux

2019;316:E34-E42

The adjusted mean 36-month Psychomotor Development Index and Mental Development Index scores of the highly and lower exposed groups differed by only 7.1 and 3.0 points, respectively, but the proportion of delayed children in the high-exposure group, compared with the low-exposure group, was 5 times greater for the Psychomotor Development Index and 2.4 times greater for the Mental Development Index, increasing the number of children possibly needing early intervention services