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[PubMed] 163: Zheng L, Szab C, Kern TS
Systematic review of antiretroviral-associated lipodystrophy: lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction
Oncogene 19 , 10771084 (2000)

While mitochondria have their own antioxidant defenses, including mitochondrial SOD, these defenses are often insufficient to neutralize the high levels of ROS produced during oxidative phosphorylation, especially if mitochondrial function is compromised
