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[4] [16] [26] While bromantane can inhibit the reuptake of serotonin, dopamine, and to a lesser extent norepinephrine in vitro in rat brain tissue, the concentrations required to do so are extremely high (50500 M) and likely not clinically relevant
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However, at higher doses or in the presence of oxidative stress and transition metals, curcumin can also interfere with COX-1 activity
