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Mechanisms of TNF-alpha and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis

doi:10.1016/j.jagp.2016.01.134 Bilyukov RG, Nikolov MS, Pencheva VP, et al

supports cellular redox balance, detox pathways, and immune function.* Vitamin C pairs synergistically with glutathione, helping regenerate and stabilize the bodys antioxidant network.* Liposomal matrix (glycerin, MCTs, phospholipids) creates a stable gel that protects glutathione and promotes cellular uptake

These effects of E2 are mediated via MC4 receptor because E2 is unable to induce anorexia when the MC4 receptor antagonists Shu 9119 or agouti-related peptide (AgRP) are applied concomitantly with E2 administration in rats (70)