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Neuroprotective effect of resveratrol via activation of Sirt1 signaling in a rat model of combined diabetes and Alzheimers disease

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In the model proposed by Lee, homocysteine is shunted away from the methionine synthesis pathway and toward the GSH synthesis pathway, creating a relative deficiency of methyl donors in order to keep up with increased demand for the glutathione needed for POP conjugation ( Fig 3 )

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[PMC free article: PMC2882727] [PubMed: 20237389] 532

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Speisky H, Shahidi F, Costa De Camargo A, Fuentes J

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