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Description
The only FDA-approved medical therapies for IC are pentoxifylline, cilostazol, and a phosphodiesterase III (PDE3) inhibitor [49]

SARS-CoV-2 ORF6 protein has also been shown to dysregulate redox homeostasis by decreasing Nrf2 expression, which can enhance viral replication 69

We followed the methods guidelines in the Cochrane Handbook for systematic reviews,26 the reporting guidelines in the PRISMA-NMA and PRISMA-IPD statements7 8 and evaluated credibility of findings using CINeMA.15 Compared with previous systematic reviews, we included a larger number of studies and/or studies with shared IPD, compared in a wider range of cognitive enhancers.6 27 Our results are in agreement with previous studies overall

Administration Key The "Unit" Math: Calculations above use a standard U-100 Insulin Syringe
