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Advances in physiology education, 43,3 Pressl, C., Brandner, P., Schaffelhofer, S., Blackmon, K., Dugan, P., Holmes, M., Thesen, T., Kuzniecky, R., Devinsky, O., & Freiwald, W

Dissociative anesthetics (ketamine and nitrous oxide) impair glutamatergic neurotransmission and mitochondrial function, contributing to excitotoxicity and neurodegeneration

36 Hence, the PPP may play a dual role in the regulation of redox homeostasis

We also summarize newly proposed mechanisms associated with hepatoprotection and tumor suppression, such as attenuation of hepatocellular stress through inhibition of the NEDD9/FAK/AKT cascade and a potential role in cell-cycle regulation via the HDAC/p21 axisalthough the latter remains to be validated in MASLD-specific models