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Older Adults: As we age, stomach acid production can decrease, making B12 absorption more challenging

Another natural compound, trigonelline, a methylated form of nicotinic acid, is a newly discovered NAD + precursor able to increase NAD + in multiple species, with preclinical implications for use in sarcopenia, and for muscle and cognitive decline in aging 124,130,131

10.1038/s41392-023-01577-3 112 ReidM.SpenceJ.NwokochaM.PalaciosJ.NwokochaC

Peptide therapies like AOD9604 or tesamorelin can play a complementary role in bodycomposition and metabolic wellness, but outside of tesamorelins HIV indication, their weightloss evidence base is smaller and they should be framed as adjunctive tools rather than replacements for wellstudied GLP1 treatments