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Although randomized controlled designs would further clarify the effects of PBM on oxidative stress and inflammatory pathways, the inclusion of RT-only comparison groups raises ethical concerns given existing guideline recommendations supporting PBM for mucositis management

For example, in order to maintain intracellular redox homeostasis and build a powerful antioxidant defense, cancer cells are typically characterized by high level of antioxidants, especially GSH with a high concentration of 10 mM, which is approximately ten times higher than that in normal cells (Labarrere and Kassab, 2022)

D., Kamikura D., Fournier T., et al